Alpha-humulène

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Nom de la substance

Alpha-humulène (autre nom invalide : alpha-caryophyllène)

Famille moléculaire

Sesquiterpène monocyclique (hydrocarbure sesquiterpénique, isomère du béta-caryophyllène

Source végétale

Propriétés

  • Anti-inflammatoire [1], alpha-humulène et trans-caryophyllène inhibent l’activation LPS-induite du NF-kappaB et la migration des neutrophiles [2]
  • Antalgique [3], [4]
  • Antitumoral [5]
  • Actuellement en recherches comme anti-cancéreux : travaux d'André Pichette et coll. Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Université du Québec, Chicoutimi [6], [7]
    • Cancers du sein, poumon, côlon, peau

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF, Calixto JB. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol. 2007 Aug 27;569(3):228-36. PMID 17559833
  2. ↑ Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol. 2007 Apr 30. PMID 17471174
  3. ↑ Chaves, J. S., Leal, P. C., Pianowisky, L., & Calixto, J. B. (2008). Pharmacokinetics and tissue distribution of the sesquiterpene alpha-humulene in mice. Planta medica, 74(14), 1678–1683. https://doi.org/10.1055/s-0028-1088307
  4. ↑ Martim JKP, Maranho LT, Costa-Casagrande TA. Review: Role of the chemical compounds present in the essential oil and in the extract of Cordia verbenacea DC as an anti-inflammatory, antimicrobial and healing product. J Ethnopharmacol. 2021 Jan 30;265:113300. doi: 10.1016/j.jep.2020.113300. PMID 32871237
  5. ↑ Sylvestre M, Pichette A, Longtin A, Nagau F, Legault J. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J Ethnopharmacol. 2006 Jan 3;103(1):99-102. PMID 16168586
  6. ↑ Pichette A, Larouche P-L, Lebrun M, Legault J. Composition and antibacterial activity of Abies balsamea essential oil. Phytotherapy Research, 2006, Vol 20 (5), pp 371–373. PMID 16619365
  7. ↑ Legault J, Dahl W, Debiton E, Pichette A, Madelmont JC. Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action. Planta Med. 2003 May;69(5):402-7. PMID 12802719
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