Béta-élémène

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Nom de la substance

Béta-élémène

Famille moléculaire

Hydrocarbure sesquiterpénique

Source végétale

Propriétés

  • Propriétés anticancéreuses [1], [2], [3], [4], [5], [6], induit l'activité des caspase-3, -7, -9, diminue l'expression de Bcl-2, entraine la libération de cytochrome c et augmente la concentration de caspase-9 et de poly(ADP-ribose) polymérase (dans cellules NSCLC épithéliales bronchiques et fibroblastiques de la langue), inhibe la prolifération des cellules de cancer ovarien résistantes au cis-platine, forte synergie avec le cis-platine [7]
  • Inducteur d'apoptose, pourrait agir dans les leucémies et les tumeurs solides, le cancer du poumon (NSCLC), lignées cellulaires H460 et A549, en synergie avec le cis-platine [8], cancer de la prostate [9], cancer du sein [10], cancer de l'estomac [11]
  • Antitumoral dans cancers du poumon et du colon [12], les gliomes malins [13], [14], [15], [16], [17]
  • Néanmoins, diverses méta-analyses mentionnent une faible qualité méthodologique et demandent confirmation [18]
  • Le bêta-élémène induit l'apoptose mitochondriale des synoviocytes de type fibroblastes, intérêt dans la polyarthrite rhumatoïde [19]

Effet thérapeutique

  • Diminue la synthèse et le dépôt excessif de collagène dans les cicatrisations hypertrophiques et les chéloïdes [20]

Effets indésirables

Bibliographie

  1. ↑ Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad JE, Flynn DC, Reed E, Li QQ. Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci. 2005 Apr;62(7-8):881-93. PMID 15868411
  2. ↑ Zhao J, Li QQ, Zou B, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 2007 Aug;31(2):241-52.
  3. ↑ Edris AE. Anti-cancer properties of Nigella spp. Essential oils and their major constituents, thymoquinone and beta-elemene. Curr Clin Pharmacol. 2009 Jan;4(1):43-6. PMID 19149500
  4. ↑ Yu Z, Wang R, Xu L, Dong J, Jing Y. N-(beta-Elemene-13-yl)tryptophan methyl ester induces apoptosis in human leukemia cells and synergizes with arsenic trioxide through a hydrogen peroxide dependent pathway. Cancer Lett. 2008 Sep 28;269(1):165-73.
  5. ↑ Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008 Jun 8;264(1):127-34.
  6. ↑ Dai ZJ, Tang W, Lu WF, Gao J, Kang HF, Ma XB, Min WL, Wang XJ, Wu WY. Antiproliferative and apoptotic effects of β-elemene on human hepatoma HepG2 cells. Cancer Cell Int. 2013 Mar 14;13(1):27. doi: 10.1186/1475-2867-13-27. PMID 23496852 texte intégral
  7. ↑ Li X, Wang G, Zhao J, Ding H, Cunningham C, Chen F, Flynn DC, Reed E, Li QQ. Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase. Cell Mol Life Sci. 2005 Apr;62(7-8):894-904. PMID 15868412
  8. ↑ Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 2009 Jul;22(1):161-70. PMID 19513519
  9. ↑ Li QQ, Wang G, Huang F, Banda M, Reed E. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug;62(8):1018-27. doi: 10.1111/j.2042-7158.2010.01135.x. PMID 20663036
  10. ↑ Guan C, Liu W, Yue Y, Jin H, Wang X, Wang XJ. Inhibitory effect of β-elemene on human breast cancer cells. Int J Clin Exp Pathol. 2014 Jun 15;7(7):3948-56. eCollection 2014. PMID 25120771
  11. ↑ Liu JS, He SC, Zhang ZL, Chen R, Fan L, Qiu GL, Chang S, Li L, Che XM. Anticancer effects of β-elemene in gastric cancer cells and its potential underlying proteins: A proteomic study. Oncol Rep. 2014 Dec;32(6):2635-47. doi: 10.3892/or.2014.3490. PMID 25333415
  12. ↑ Sylvestre M, Pichette A, Longtin A, Nagau F, Legault J. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J Ethnopharmacol. 2006 Jan 3;103(1):99-102. PMID 16168586
  13. ↑ Zhou HY, Shen JK , Hou JS , Qiu YM, Luo QZ. Experimental study on apoptosis induced by elemene in glioma cells. Aizheng = Chinese Journal of Cancer, 01 Sep 2003, 22(9):959-963. PMID 12969529
  14. ↑ Li CL, Chang L, Guo L, Zhao D, Liu HB, Wang QS, Zhang P, Du WZ, Liu X, Zhang HT, Liu Y, Zhang Y, Xie JH, Ming JG, Cui YQ, Sun Y, Zhang ZR, Jiang CL. β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of Bax and Fas/ FasL and downregulation of Bcl-2. Asian Pacific Journal of Cancer Prevention : APJCP [01 Jan 2014, 15(23):10407-10412] PMID 25556484
  15. ↑ Zhang H, Xu F, Xie T, Jin H, Shi L. β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein. Oncol Rep. 2012 Dec;28(6):2083-90. doi: 10.3892/or.2012.2022. PMID 22965456
  16. ↑ Xu YH, Dong B, Luo QZ, Zhou HY, Jia YC, Yang YF, Wang YZ. Influence of elemene on the expression of Bcl-2 family genes in rat C6 glioma cells. Zhonghua yi xue za zhi [01 Jun 2005, 85(24):1700-1703] PMID:16251076
  17. ↑ Yao YQ, Ding X, Jia YC, Huang CX, Wang YZ, Xu YH. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. 2008 Jun 8;264(1):127-34. doi: 10.1016/j.canlet.2008.01.049. PMID 18442668
  18. ↑ Peng X, Zhao Y, Liang X, Wu L, Cui S, Guo A, Wang W. Assessing the quality of RCTs on the effect of beta-elemene, one ingredient of a Chinese herb, against malignant tumors. Contemp Clin Trials. 2006 Feb;27(1):70-82. doi: 10.1016/j.cct.2005.07.002. PMID 16243588.
  19. ↑ Zou S, Wang C, Cui Z, Guo P, Meng Q, Shi X, Gao Y, Yang G, Han Z. β-Elemene induces apoptosis of human rheumatoid arthritis fibroblast-like synoviocytes via reactive oxygen species-dependent activation of p38 mitogen-activated protein kinase. Pharmacol Rep. 2016 Feb;68(1):7-11. doi: 10.1016/j.pharep.2015.06.004. PMID 26721344.
  20. ↑ Guo Q, Li Y, Chen Y, Ji J, Zheng S, Xu X, Zhang B, Ye J. β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts. IUBMB Life. 2022 Jun;74(6):508-518. doi: 10.1002/iub.2614. PMID 35294085.
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