Taxifoline
(Redirigé depuis Dihydroquercétine)
Nom de la substance
Taxifoline, dihydroquercétine
Famille moléculaire
Flavonoïde (flavanone)
Source végétale
- Bois de mélèze Larix sibirica Ledeb, Larix dahurica Turcz. ex Trautv., chardon-Marie, pin sylvestre Pinus sylvestris, cannelle de Magellan Drymis winteri
- La production de taxifoline est plus importante dans les populations de pins des régions plus chaudes [1]
Propriétés
- Anti-oxydant
- Anti-inflammatoire
- Hypotenseur
- Diminue la synthèse hépatique de lipides, diminue l’Apo-B, augmente l’Apo-A1, inhibe l’activité de l’HMG-CoA reductase (de 47 ± 7%) [2], [3]
- Améliore la récupération de l'activité des enzymes mitochondriales dans les muscles squelettiques de la souris âgée [4]
- Hépatoprotecteur par effet anti-oxydant [5]
- Protection vis-à-vis de l'irradiation [6]
- Chimio-prévention par activité sur les enzymes de phase 2 et la quinone reductase [7]
- Neuroprotecteur [8], [9]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ P Lebreton, C Laracine-Pittet, C Bayet, J Lauranson. Variabilité polyphénolique et systématique du pin sylvestre Pinus sylvestris L. Ann. For. Sci. 47 (1990) 117-130
- ↑ Theriault, A., Q. Wang, S. C. Van Iderstine, B. Chen, A. A. Franke, and K. Adeli. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. J. Lipid Res. 2000. 41: 1969–1979
- ↑ Casaschi A, Rubio BK, Maiyoh GK, Theriault AG. Inhibitory activity of diacylglycerol acyltransferase (DGAT) and microsomal triglyceride transfer protein (MTP) by the flavonoid, taxifolin, in HepG2 cells: potential role in the regulation of apolipoprotein B secretion. Atherosclerosis. 2004 Oct;176(2):247-53. PMID 15380446
- ↑ G. E. Bronnikov, T. P. Kulagina, A. V. Aripovsky. Dietary supplementation of old mice with flavonoid dihydroquercetin causes recovery of the mitochondrial enzyme activities in skeletal muscles. Biochemistry (Mscow) supplemental series A: membrane and cell biology. Biomedical and life sciences. Volume 3, Number 4, 453-458
- ↑ Teselkin Yu O., Dihydroquercetin as a mean of antioxidative defence in rats with tetrachloromethane hepatitis, Phytotherapy Research, 2000 May, 14(3) : 495-502. PMID 10815007
- ↑ Teselkin Yu. O, Babenkova I. V, Tjukavkina N. A. Influence of dihydroquercetin on the lipid peroxidation of mice during post-radiation period. Phytotherapy research, 1998, vol. 12, n° 7, pp. 517-519 [1]
- ↑ Lee SB, Cha KH, Selenge D, Solongo A, Nho CW. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID 17541156
- ↑ Dok-Go H, Lee KH, Kim HJ, Lee EH, Lee J, Song YS, Lee YH, Jin C, Lee YS, Cho J. Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten. Brain Res. 2003 Mar 7;965(1-2):130-6. PMID 12591129
- ↑ Wang YH, Wang WY, Chang CC, Liou KT, Sung YJ, Liao JF, Chen CF, Chang S, Hou YC, Chou YC, Shen YC. Taxifolin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-oxidative effect and modulation of NF-kappa B activation. J Biomed Sci. 2006 Jan;13(1):127-41. PMID 16283433
- Patrick Trouillas, Philippe Marsal, Didier Siri, Roberto Lazzaroni, Jean-Luc Duroux. A DFT study of the reactivity of OH groups in quercetin and taxifolin antioxidants: The specificity of the 3-OH site. Food Chemistry, Volume 97, Issue 4, August 2006, Pages 679–688 [2]