Protopine
(Redirigé depuis Fumarine)
Nom de la substance
Protopine = fumarine, corydinine
Famille moléculaire
- Alcaloïde isoquinoléique
Source végétale
- Fumeterre, eschscholtzia, pavot, argémone, sanguinaire, corydale, famille des Papaveraceae
Propriétés
- Anti-histaminique, anti-allergique [1]
- Anti-inflammatoire [2]
- Sérotoninergique
- Activité benzodiazépine-like [3] par action sur le GABA
- Pourrait traiter les tremblements du fait d’un effet anticholinergique et GABA-ergique [4]
- Anti-arythmique (prévention de la fibrillation ventriculaire chez le rat) [5]
- Anticancer (?) [6], [7]
- Hépatoprotectrice dans Fumaria indica (silymarine) [8]
Effet thérapeutique
Effets indésirables
- La protopine et l'allocryptopine induisent modérément les enzymes CYP1A (cytochromes P450 CYP1A1 et CYP1A2) [9]
Bibliographie
- ↑ Sharma P, Singh G. A review of plant species used to treat conjunctivitis. Phytother Res. 2002 Feb;16(1):1-22. PMID 11807959
- ↑ S.A. SAEED, A.H. GILANI, R.U. MAJOO, B.H. SHAH, ANTI-THROMBOTIC AND ANTI-INFLAMMATORY ACTIVITIES OF PROTOPINE. Pharmacological Research, Volume 36, Issue 1, 1997, Pages 1-7, https://doi.org/10.1006/phrs.1997.0195.
- ↑ Kardos J, Blaskó G, Simonyi M. Enhancement of gamma-aminobutyric acid receptor binding by protopine-type alkaloids. Arzneimittelforschung. 1986 Jun;36(6):939-40. PMID 3017370
- ↑ Rektor I, Rektorová I, Suchý V. How to treat tremor. J Neurol. 2004 May;251(5):525-8. PMID 15164183
- ↑ Burtsev VN, Dormidontov EN, Saliaev VN. Prevention of ventricular fibrillation with the aid of protopine in animal experiments. Kardiologiia. 1978 Apr;18(4):76-9. PMID 671972
- ↑ He K, Gao JL. Protopine Inhibits Heterotypic Cell Adhesion in MDA-MB-231 Cells Through Down-Regulation of Multi-Adhesive Factors. Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):415-24. eCollection 2014. PMID 25435628
- ↑ Bournine L, Bensalem S, Peixoto P, Gonzalez A, Maiza-Benabdesselam F, Bedjou F, Wauters JN, Tits M, Frédérich M, Castronovo V, Bellahcène A. Revealing the anti-tumoral effect of Algerian Glaucium flavum roots against human cancer cells. Phytomedicine. 2013 Oct 15;20(13):1211-8. doi: 10.1016/j.phymed.2013.06.007. PMID 23860409
- ↑ Rathi A1, Srivastava AK, Shirwaikar A, Singh Rawat AK, Mehrotra S. Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine. Phytomedicine. 2008 Jun;15(6-7):470-7. doi: 10.1016/j.phymed.2007.11.010. PMID 18164606
- ↑ Vrba J, Vrublova E, Modriansky M, Ulrichova J. Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR.Toxicol Lett. 2011 Jun 10;203(2):135-41. doi: 10.1016/j.toxlet.2011.03.015. PMID 21419197