Verbascoside

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Nom de la substance

Verbascoside (= actéoside)

Famille moléculaire

Source végétale

Propriétés

  • Immuno-modulant [1]
  • Anti-inflammatoire par inhibition de la 5-lipoxygénase et inhibition de la cyclo-oxygénase Cox2 [2], [3]
  • Antalgique [4]
  • Antiviral (Herpes-virus) [5]
  • Inhibiteur de la protéine kinase C [6]
  • Réduit les dommages oxydatifs cérébraux induits par l'héroïne [7]
  • Effet reverse sur les cellules de cancer gastrique humain MGc80-3 [8], effet antitumoral par modulation de la télomérase [9]
  • Effet aphrodisiaque ( ?)
  • Accroissement de l’activité superoxyde dismutase ( ?)
  • Inhibiteur de la monoamine-oxydase (?)

Effet thérapeutique

  • Prise de poids, obésité [10]

Effets indésirables

Bibliographie

  1. Akbay P, Calis I, Undeger U, Basaran N, Basaran AA. In vitro immunomodulatory activity of verbascoside from Nepeta ucrainica L. Phytother Res. 2002 Sep;16(6):593-5. PMID 12237823
  2. Sahpaz S, Garbacki N, Tits M, Bailleul F. Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare. J Ethnopharmacol. 2002 Mar;79(3):389-92. PMID 11849848
  3. Speranza L, Franceschelli S, Pesce M, Reale M, Menghini L, Vinciguerra I, De Lutiis MA, Felaco M, Grilli A. Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytother Res. 2010 Sep;24(9):1398-404. doi: 10.1002/ptr.3173. PMID 20812283
  4. Isacchi B, Iacopi R, Bergonzi MC, Ghelardini C, Galeotti N, Norcini M, Vivoli E, Vincieri FF, Bilia AR. Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol. 2011 Apr;63(4):594-601. doi: 10.1111/j.2042-7158.2011.01264.x. PMID 21401613
  5. Martins FO, Esteves PF, Mendes GS, Barbi NS, Menezes FS, Romanos MT. Verbascoside isolated from Lepechinia speciosa has inhibitory activity against HSV-1 and HSV-2 in vitro. Nat Prod Commun. 2009 Dec;4(12):1693-6. PMID 20120109
  6. J. M. Herbert, J. P. Maffrand, K. Taoubi, J. M. Augereau, I. Fouraste, J. Gleye. Verbascoside Isolated from Lantana camara, an Inhibitor of Protein Kinase C. J. Nat. Prod., 1991, 54 (6), pp 1595–1600
  7. Zheng Qiusheng, Zhang Yuntao, Zheng Rongliang, Guo Dean, Li Changling. Effects of verbascoside and luteolin on oxidative damage in brain of heroin treated mice. Pharmazie, 2005, Volume 60, issue 7, Pages 539-543
  8. Li Ji, Zheng Yun, Zhou Hong, Su Baoning, Zheng Rongliang. Differentiation of Human Gastric Adenocarcinoma Cell Line MGc80-3 Induced by Verbascoside. Planta Med 1997; 63(6): 499-502 [1]
  9. Fangxin Zhang, Zhongjian Jia, Zhiyun Deng, Yaming Wei, Rongliang Zheng, Lijing Yu. In Vitro Modulation of Telomerase Activity, Telomere Length and Cell Cycle in MKN45 Cells by Verbascoside. Planta Med 2002; 68(2): 115-118
  10. Herranz-López M, Barrajón-Catalán E, Segura-Carretero A, Menéndez JA, Joven J, Micol V. Lemon verbena (Lippia citriodora) polyphenols alleviate obesity-related disturbances in hypertrophic adipocytes through AMPK-dependent mechanisms. Phytomedicine. 2015 Jun 1;22(6):605-14. doi: 10.1016/j.phymed.2015.03.015. PMID 26055125