Acide tormentique
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Nom de la substance
Acide tormentique, acide jacarandique
Famille moléculaire
Source végétale
- Eriobotrya japonica, Poterium ancistroides, Plectranthus amboinicus, Callistemon citrinus, Rosa rugosa, Potentilla chinensis
Propriétés
- Antidiabétique, effet comparable à celui du glibenclamide, en augmentant la sécrétion d’insuline par les ilots de Langerhans [1], [2]
- Évite l’induction de diabète et d’hyperlipidémie induites par un régime riche en graisses [3]
- Anti-inflammatoire, régulation à la baisse de l'iNOS, de la COX-2 et du TNF-α via la régulation négative de la voie NF-κB [4]
- Hépatoprotecteur [5], protège de la toxicité du paracétamol
- Neuroprotecteur (potentialités dans la maladie d'Alzheimer) [6]
- Cardioprotecteur, hypolipidémiant, antioxydant, antimicrobien [7]
- Effet anti-biofilm sur souches de Staphylococcus aureus [8]
- Antifongique (Candida albicans, C. tropicalis) [9]
- Anticancéreux, inhibe la prolifération et induit l'apoptose de cellules d'hépatome LX-2 en bloquant la voie de signalisation NF-κB [10]
Effet thérapeutique
Effets indésirables
Bibliographie
- ↑ Ivorra MD, Paya M, Villar A. Hypoglycemic and insulin release effects of tormentic acid: a new hypoglycemic natural product. Planta Med. 1988 Aug;54(4):282-5. doi: 10.1055/s-2006-962433. PMID 3065804.
- ↑ Villar A, Payá M, Hortigüela MD, Cortes D. Tormentic acid, a new hypoglycemic agent from Poterium ancistroides. Planta Med. 1986 Feb;(1):43-5. doi: 10.1055/s-2007-969065. PMID 3085116.
- ↑ Wu JB, Kuo YH, Lin CH, Ho HY, Shih CC. Tormentic acid, a major component of suspension cells of Eriobotrya japonica, suppresses high-fat diet-induced diabetes and hyperlipidemia by glucose transporter 4 and AMP-activated protein kinase phosphorylation. J Agric Food Chem. 2014 Nov 5;62(44):10717-26. doi: 10.1021/jf503334d. Epub 2014 Oct 27. PMID 25317836.
- ↑ An HJ, Kim IT, Park HJ, Kim HM, Choi JH, Lee KT. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2011 Apr;11(4):504-10. doi: 10.1016/j.intimp.2011.01.002. Epub 2011 Jan 13. PMID 21237302.
- ↑ Jiang WP, Huang SS, Matsuda Y, Saito H, Uramaru N, Ho HY, Wu JB, Huang GJ. Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice. Molecules. 2017 May 18;22(5):830. doi: 10.3390/molecules22050830. PMID 28524081; PMCID: PMC6154347.
- ↑ Cui W, Sun C, Ma Y, Wang S, Wang X, Zhang Y. Neuroprotective effect of tormentic acid against memory impairment and neuro‑inflammation in an Alzheimer's disease mouse model. Mol Med Rep. 2020 Aug;22(2):739-750. doi: 10.3892/mmr.2020.11154. Epub 2020 May 18. PMID 32468017; PMCID: PMC7339752.
- ↑ Olech M, Ziemichód W, Nowacka-Jechalke N. The Occurrence and Biological Activity of Tormentic Acid-A Review. Molecules. 2021 Jun 22;26(13):3797. doi: 10.3390/molecules26133797. PMID 34206442; PMCID: PMC8270333.
- ↑ Ghosh C, Das MC, Acharjee S, Bhattacharjee S, Sandhu P, Kumari M, Bhowmik J, Ghosh R, Banerjee B, De UC, Akhter Y, Bhattacharjee S. Combating Staphylococcus aureus biofilm formation: the inhibitory potential of tormentic acid and 23-hydroxycorosolic acid. Arch Microbiol. 2023 Dec 18;206(1):25. doi: 10.1007/s00203-023-03762-y. PMID 38108905.
- ↑ Bvumbi C, Chi GF, Stevens MY, Mombeshora M, Mukanganyama S. The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans. ScientificWorldJournal. 2021 Sep 21;2021:8856147. doi: 10.1155/2021/8856147. PMID 34594161; PMCID: PMC8478599.
- ↑ Li Y, Zhang X, Wei Y, Wen S, Lin X, Huang Q. [Tormentic acid inhibits proliferation and promotes apoptosis of LX-2 human hepatic stellate cells via blocking NF-κB signaling pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2021 Oct;37(10):897-903. Chinese. PMID 34670666.