Alpha-terpinéol

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Nom de la substance

Alpha-terpinéol, α-terpinéol

Famille moléculaire

Alcool monoterpénique

Source végétale

Propriétés

  • Antibactérien [1], vis-à-vis de Staphylococcus aureus [2], antifongique
  • Antiviral [4]
  • Anti-inflammatoire [5] et antalgique
  • Gastroprotecteur [6]
  • Antihypertenseur, vasorelaxant probablement via la libération de NO [7]
  • Anti-allergique [8]
  • Biopesticide [9]
  • Rafraîchissant au contact de la peau

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Kotan R, Kordali S, Cakir A. Screening of antibacterial activities of twenty-one oxygenated monoterpenes. Z Naturforsch C J Biosci. 2007 Jul-Aug;62(7-8):507-13. PMID 17913064
  2. Carson CF, Mee BJ, Riley TV. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrob Agents Chemother. 2002 Jun;46(6):1914-20. http://cat.inist.fr/?aModele=afficheN&cpsidt=14187758
  3. Chelsea J. Papadopoulos, Christine F. Carson, Barbara J. Chang, Thomas V. Riley. Role of the MexAB-OprM Efflux Pump of Pseudomonas aeruginosa in Tolerance to Tea Tree (Melaleuca alternifolia) Oil and Its Monoterpene Components Terpinen-4-ol, 1,8-Cineole, and α-Terpineol. Appl. Environ. Microbiol. March 2008 vol. 74 no. 6 1932-1935
  4. Astani A, Reichling J, Schnitzler P. Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytother Res. 2010 May;24(5):673-9. PMID 19653195
  5. Nogueira MN, Aquino SG, Rossa Junior C, Spolidorio DM. Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages. Inflamm Res. 2014 Sep;63(9):769-78. doi: 10.1007/s00011-014-0749-x. PMID 24947163
  6. Souza R, Cardoso M, Menezes C, Silva J, De Sousa D, Batista J. Gastroprotective activity of α-terpineol in two experimental models of gastric ulcer in rats. Daru. 2011;19(4):277-81. PMID 22615669
  7. Ribeiro TP, Porto DL, Menezes CP, Antunes AA, Silva DF, De Sousa DP, Nakao LS, Braga VA, Medeiros IA. Unravelling the cardiovascular effects induced by alpha-terpineol: a role for the nitric oxide-cGMP pathway. Clin Exp Pharmacol Physiol. 2010 Aug;37(8):811-6. doi: 10.1111/j.1440-1681.2010.05383.x. PMID 20374260
  8. Pina LTS, Ferro JNS, Rabelo TK, Oliveira MA, Scotti L, Scotti MT, Walker CIB, Barreto EO, Quintans Júnior LJ, Guimarães AG. Alcoholic monoterpenes found in essential oil of aromatic spices reduce allergic inflammation by the modulation of inflammatory cytokines. Nat Prod Res. 2019 Jun;33(12):1773-1777. doi: 10.1080/14786419.2018.1434634. PMID 29394874
  9. Chiasson Hélène, Beloin Nadine. Les huiles essentielles, des biopesticides « nouveau genre ». Bulletin de la Société d’entomologie du Québec, Antennae 2007, vol. 14, no 1