Géraniine

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Nom de la substance

Géraniine

Famille moléculaire

Source végétale

Propriétés

  • Astringent, antidiarrhéique
  • Anti-hypertenseur [1], [2], par effet d'inhibition de l'enzyme de conversion de l'angiotensine [3]
  • Antalgique [4]
  • Antiviral (enterovirus) [5], inhibition des virus Zika et de la dengue [6], Herpes virus I et II [7]
  • Propriétés immunomodulantes, inhibe la libération du TNF-alpha (tumor necrosis factor-alpha) [8], dans les cellules de cancer ovarien [9]
  • Médiateur d'apoptose dans les cellules de mélanome humain [10]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Shyr-Yi Lin, Ching-Chiung Wang, Yeh-Lin Lu, Wen-Chun Wu, Wen-Chi Hou. Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria. Food and Chemical Toxicology, Volume 46, Issue 7, 2008, Pages 2485-2492, https://doi.org/10.1016/j.fct.2008.04.007.
  2. Cheng, J. T., Chang, S. S., & Hsu, F. L. (1994). Antihypertensive action of geraniin in rats. Journal of pharmacy and pharmacology, 46(1), 46-49.
  3. Ueno, H., Horie, S., Nishi, Y., Shogawa, H., Kawasaki, M., Suzuki, S., ... & Morita, N. (1988). Chemical and Pharmaceutical Studies on Medicinal Plants in Paraguay, Geraniin, an Angiotensin-Converting Enzyme Inhibitor from" Paraparai Mi," Phyllanthus niruri. Journal of natural products, 51(2), 357-359.
  4. Miguel, O. G., Calixto, J. B., Santos, A. R., Messana, I., Ferrari, F., Cechinel Filho, V., ... & Yunes, R. A. (1996). Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from Phyllanthus sellowianus. Planta Medica, 62(02), 146-149.
  5. Yajun Yang, Lianfeng Zhang, Xiaoxu Fan, Chuan Qin, Jiangning Liu. Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo. Bioorganic & Medicinal Chemistry Letters, Volume 22, Issue 6, 2012, Pages 2209-2211, https://doi.org/10.1016/j.bmcl.2012.01.102.
  6. Haddad JG, Grauzdytė D, Koishi AC, Viranaicken W, Venskutonis PR, Nunes Duarte Dos Santos C, Desprès P, Diotel N, El Kalamouni C. The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish. Molecules. 2020 May 15;25(10):2316. doi: 10.3390/molecules25102316. PMID 32429073
  7. Chien-Min Yang, Hua-Yew Cheng, Ta-Chen Lin, Lien-Chai Chiang, Chun-Ching Lin. The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-β-d-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection. Journal of Ethnopharmacology, Volume 110, Issue 3, 2007, Pages 555-558, https://doi.org/10.1016/j.jep.2006.09.039.
  8. Okabe, S., Suganuma, M., Imayoshi, Y., Taniguchi, S., Yoshida, T., & Fujiki, H. (2001). New TNF-α releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki. Biological and Pharmaceutical Bulletin, 24(10), 1145-1148.
  9. Wang X, et al. Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression. J Biochem Mol Toxicol. 2017 Sep;31(9)
  10. Lee, Jang-Chang; Tsai, Chih-Yen; Kao, Jung-Yie; Kao, Ming-Ching; Tsai, Shih-Chang; Chang, Chih-Shiang; Huang, Li-Jiau; Kuo, Sheng-Chu; et al. (2008). "Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells". Molecular Nutrition & Food Research. 52 (6): 655–63. doi:10.1002/mnfr.200700381. PMID 18435487.